NVIDIA BioNeMo RFD4-Proteina
Open BioNeMo protein-design model built with the Baker Lab; NVIDIA claims ~13x faster generation than RFdiffusion3.
Overview
NVIDIA BioNeMo RFD4-Proteina is an open model developed with the Baker Lab at the University of Washington Institute for Protein Design. It generates protein sequences and 3D structures for protein design tasks. NVIDIA, in its October 21, 2026 GTC Berlin open-models post, claims leading performance across more than 10 tasks and about 13x faster generation than RFdiffusion3 on a 200-amino-acid benchmark. These figures are NVIDIA's own and the post does not give a parameter count. It is available as a NIM microservice on build.nvidia.com, on GitHub and on Hugging Face.
This is a sourced directory entry. Features and capabilities are reported in the linked sources; this entry does not document independent Aymorphic testing.
Key features
- Generates protein sequences and 3D structures
- Claimed leading performance across more than 10 protein-design tasks
- Claimed ~13x faster than RFdiffusion3 on a 200-amino-acid benchmark
- Available as NIM microservice, on GitHub and on Hugging Face
Use cases
- De novo protein binder and scaffold design
- Screening large numbers of candidate protein structures quickly
Pricing
Unknown; model license and NIM pricing are not stated in the announcement.
Pricing reflects the source record and may change. Confirm current terms with the provider.
Dates and sources
- Released
- 21 Oct 2026
- Record updated
- 27 Oct 2026
- Record last checked
- 27 Oct 2026